Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591584 | Bioorganic & Medicinal Chemistry Letters | 2014 | 21 Pages |
Abstract
Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review, we highlight selected examples from the primary medicinal chemistry literature during the last three years to demonstrate the versatility of spiro scaffolds. With recent progress in synthetic methods providing access to spiro building blocks, spiro scaffolds are likely to be used more frequently in drug discovery.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yajun Zheng, Colin M. Tice, Suresh B. Singh,