Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591590 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Recent discoveries of important pharmacological properties have drawn attention to the reactivity of HNO (azanone, nitroxyl) with biologically relevant substrates. Apart from its role in thiol oxidation, HNO has been reported to have nitrosative properties, for example, with tryptophan resulting in N-nitrosotryptophan formation. We have investigated the reactivity of HNO with tryptophan and small peptides containing either tryptophan or both a tryptophan and a cysteine residue. Our results point to the more reactive nature of cysteine towards HNO compared with tryptophan.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gizem Keceli, Cathy D. Moore, John P. Toscano,