Article ID Journal Published Year Pages File Type
10591643 Bioorganic & Medicinal Chemistry Letters 2014 5 Pages PDF
Abstract
The incidence of cognitive disorders such as Alzheimer's disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the proline transporter (PROT), a high affinity Na+/Cl−-dependent transporter, indicated its potential as a novel therapeutic target for cognition improvement. Herein we report our investigation into a novel class of PROT inhibitors.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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