| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591659 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A series of novel 1,5-benzodiazepine-2,4-dione derivatives with C-6 amide substituents were designed and synthesized using three-component reactions. The preliminary assays showed that most of them displayed moderate to good antitumor activities against human lung carcinoma (A549), human breast epithelial carcinoma (MCF-7), human colon carcinoma (HCT116), human cervical carcinoma (Hela) and Lewis lung carcinoma (2LL). Exhilaratingly, the activity level of 6m rivaled that of 5-Fluorouracil (5-Fu) against MCF-7 cell lines, which might be used as novel lead scaffold for potential anticancer development.
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Authors
Yinbo Chen, Vanminh Le, Xiaoyong Xu, Xusheng Shao, Jianwen Liu, Zhong Li,