| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591679 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A series of 9α-hydroxyamino-parthenolides 3-10, 9β-hydroxyamino-parthenolides 11-13 and 9α-hydroxy-1β,10α-epoxyamino-parthenolides 15-19 were efficiently synthesized starting from 9α-hydroxyparthenolide 1 and 9β-hydroxyparthenolide 2, which were isolated from Anvillea radiata. Compounds 1-13 and 15-19 were evaluated for their in vitro anticancer activity by the MTT colorimetric assay against one murine and six human cancer cell lines. This work provides new details about the structural requisites for anticancer activity.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mohamed Moumou, Abderrahman El Bouakher, Hassan Allouchi, Ahmed El Hakmaoui, Ahmed Benharref, Véronique Mathieu, Gérald Guillaumet, Mohamed Akssira,