Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591686 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between γ-hydroxybutenolides and aromatic aldehydes. The following outlines our findings that these spirocycles are potently cytotoxic and have a dramatic structure-function profile that provides excellent insight into the structural features required for this potency.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael P. D'Erasmo, William B. Smith, Alberto Munoz, Poornima Mohandas, Andrew S. Au, Jason J. Marineau, Luis E.N. Quadri, James E. Bradner, Ryan P. Murelli,