| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591697 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The synthesis and structure-activity relationships of a novel aryl uracil series which contains a fused 5,6-bicyclic ring unit for HCV NS5B inhibition is described. Several analogs display replicon cell culture potencies in the low nanomolar range along with excellent rat pharmacokinetic values.
Related Topics
Physical Sciences and Engineering
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Authors
A. Chris Krueger, John T. Randolph, David A. DeGoey, Pamela L. Donner, Charles A. Flentge, Douglas K. Hutchinson, Dachun Liu, Christopher E. Motter, Todd W. Rockway, Rolf Wagner, David W.A. Beno, Gennadiy Koev, Hock B. Lim, Jill M. Beyer, Rubina Mondal,