| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591702 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
PMQA, an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn2+-induced red-shift of emission (85Â nm), and was successfully applied to image zinc in living cells. Compared to 2:1 stoichiometry in PMQA-Zn2+, PMQA-Cu2+ shows 1:1 composition. Both nitrogen atoms from the aminoquinoline are missing in binding of zinc, while they are critically involved in Cu2+ chelation. The structure difference between PMQA-Zn2+ and PMQA-Cu2+ might shed light in designing novel zinc probes without suffering from copper interference.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Liangwei Zhang, Xuemei Cui, Jinyu Sun, Yuli Wang, Weishuang Li, Jianguo Fang,