Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591704 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
When the drug product of brotizolam (1) is decomposed according to the interview form and patent, hydrolysate (2) is obtained, but its physicochemical data are still missing. To elucidate the structure based on a spectroscopic approach, the above-mentioned degradation product was isolated and applied to the structural analysis. As a result, the structure of decomposed product was found to be different from that of 2. In this report, its isolation and structure elucidation by NMR and MS spectra are described.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Yoshinori Sugimoto, Aya Kugimiya, Yoshifumi Yoshimura, Hideo Naoki,