| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591705 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic replacements is presented, as well as side-chain SAR of the more potent thiadiazole ring system leading to thiadiazole 4c as a novel antiplatelet agent.
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Authors
Réjean Ruel, Alexandre L'Heureux, Carl Thibeault, Jean-Paul Daris, Alain Martel, Laura A. Price, Qimin Wu, Ji Hua, Ruth R. Wexler, Robert Rehfuss, Patrick Y.S. Lam,