| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591717 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Probestin is a potent aminopeptidase N (APN) inhibitor originally isolated from the bacterial culture broth. Here, we report probestin synthesis by solid phase peptide synthesis (SPPS) method and evaluated its activity to inhibit angiogenesis using a chicken embryo chorioallantoic membrane (CAM) assay and a CAM tumor xenograft model. Results from these studies demonstrate that probestin inhibits the angiogenic activity and tumor growth.
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Authors
Gopal Pathuri, Jessica E. Thorpe, Bryan C. Disch, Lora C. Bailey-Downs, Michael A. Ihnat, Hariprasad Gali,