| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591732 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
We describe the discovery of a series of arylsulfonyl 3-(pyridin-2-yloxy)anilines as GPR119 agonists derived from compound 1. Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties.
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Authors
Jian (Ken) Zhang, An-Rong Li, Ming Yu, Yingcai Wang, Jiang Zhu, Frank Kayser, Julio C. Medina, Karen Siegler, Marion Conn, Bei Shan, Mark P. Grillo, John Eksterowicz, Peter Coward, Jiwen (Jim) Liu,