| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591742 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
A series of benzazepinones were synthesized and evaluated as Nav1.7 sodium channel blockers. Compound 30 from this series displayed potent channel block, good oral bioavailability, and dose-dependent oral efficacy in a rat model of neuropathic pain.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott B. Hoyt, Clare London, Catherine Abbadie, John P. Felix, Maria L. Garcia, Nina Jochnowitz, Bindhu V. Karanam, Xiaohua Li, Kathryn A. Lyons, Erin McGowan, Birgit T. Priest, McHardy M. Smith, Vivien A. Warren, Brande S. Thomas-Fowlkes,