Article ID Journal Published Year Pages File Type
10591744 Bioorganic & Medicinal Chemistry Letters 2013 4 Pages PDF
Abstract
In an effort to understand the origin of blood-pressure lowering effects observed in recent clinical trials with 11β-HSD1 inhibitors, we examined a set of 11β-HSD1 inhibitors in a series of relevant in vitro and in vivo assays. Select 11β-HSD1 inhibitors reduced blood pressure in our preclinical models but most or all of the blood pressure lowering may be mediated by a 11β-HSD1 independent pathway.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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