| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591749 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
A series of novel coumarin-benzimidazole hybrids, 3-(1H-benzo[d]imidazol-2-yl)-7-(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized. Six out of the newly synthesized compounds were screened for in vitro antitumor activity against preliminary 60 tumor cell lines panel assay. A significant inhibition for cancer cells was observed with compound 8 (more than 50% inhibition) compared with other compounds and active known drug 5-fluorouracil (in some cell lines) as positive control. Compound 8 displayed appreciable anticancer activities against leukemia, colon cancer and breast cancer cell lines.
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Authors
Kamaldeep Paul, Shweta Bindal, Vijay Luxami,