| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591782 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
The first synthesis of 1â²-cyano-2â²-C-methyl pyrimidine nucleosides is described. Anti-HCV activity of these nucleosides and their nucleotide phosphoramidate prodrugs was assessed and compared to the 1â²-unsubstituted counterparts and to the related 1â²-cyano-2â²-C-methyl C-nucleoside parent of GS-6620.
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Authors
Michael R. Mish, Aesop Cho, Thorsten Kirschberg, Jie Xu, C. Sebastian Zonte, Martijn Fenaux, Yeojin Park, Darius Babusis, Joy Y. Feng, Adrian S. Ray, Choung U. Kim,