| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591785 | Bioorganic & Medicinal Chemistry Letters | 2014 | 8 Pages |
Abstract
The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Steven M. Sparks, Grace Chen, Jon L. Collins, Dana Danger, Steven T. Dock, Channa Jayawickreme, Stephen Jenkinson, Christopher Laudeman, M. Anthony Leesnitzer, Xi Liang, Patrick Maloney, David C. McCoy, David Moncol, Vincent Rash, Thomas Rimele,