Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591789 | Bioorganic & Medicinal Chemistry Letters | 2014 | 22 Pages |
Abstract
We describe the exploration of N1-aryl-substituted benzimidazoles as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The design of the compounds was guided by the co-crystal structure of a benzimidazole viral translation inhibitor in complex with the RNA target. Structure-binding activity relationships of aryl-substituted benzimidazole ligands were established that were consistent with the crystal structure of the translation inhibitor complex.
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Authors
Kejia Ding, Annie Wang, Mark A. Boerneke, Sergey M. Dibrov, Thomas Hermann,