| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591804 | Bioorganic & Medicinal Chemistry Letters | 2014 | 24 Pages |
Abstract
A series of barbigerone analogues (7a-7w, 13a-13x) were designed, synthesized and biologically evaluated for their anti-proliferative and anti-angiogenic activities. Among these compounds, compound 13a exhibited the most potent inhibitory effect on the proliferation of HUVECs, HepG2, A375, U251, B16, and HCT116 cells (IC50 = 3.80, 0.28, 1.58, 3.50, 1.09 and 0.68 μM, respectively). Compound 13a inhibited the angiogenesis in zebrafish embryo assay in a concentration-dependent manner. Furthermore, 13a also effectively inhibited the migration and capillary like tube formation of human umbilical vein endothelial cell in vitro. These results support the further investigation of this class of compounds as potential anti-proliferative and anti-angiogenesis agents.
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Authors
Guangcheng Wang, Fang Wang, Dong Cao, Yibin Liu, Ronghong Zhang, Haoyu Ye, Xiuxia Li, Lin He, Zhuang Yang, Liang Ma, Aihua Peng, Mingli Xiang, Yuquan Wei, Lijuan Chen,