| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591817 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A series of TRPA1 antagonists is described having a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine or a 1-aryloxyisoquinoline scaffold. These compounds have high ligand efficiency and favorable physical properties and may thus serve as scaffolds for further optimization.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists](/preview/png/10591817.png "First Page Preview: Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists")
Authors
Yun-Jin Hu, Miguel St.-Onge, Sébastien Laliberté, Frédéric Vallée, Shujuan Jin, Leanne Bedard, Jean Labrecque, Jeffrey S. Albert,