Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591826 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
We report the synthesis and biological evaluation of three analogues of the natural product (+)-grandifloracin (+)-1. All three analogues exhibit enhanced antiproliferative activity against PANC-1 and HT-29 cells compared to the natural product. The retention of activity in an analogue lacking the enone functional group, 9, implies this structural element is not an essential part of the (+)-grandifloracin pharmacophore.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Monika Ali Khan, Pauline J. Wood, Natasha M. Lamb-Guhren, Lorenzo Caggiano, Gabriele Kociok-Köhn, David Tosh, Simon E. Lewis,