Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591859 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
A series of linear pentamidine analogs exhibiting low cytotoxicity, active against Pneumocystis carinii, were evaluated for in vitro activities against bacterial and fungal strains. The majority of the tested bis-amidines exhibited marked activities against Gram-positive strains. In view of the fact that the highest potency was found for 1,5-bis(4-amidinophenoxy)-3-thiapentane dihydrochloride 1j with the S atom in the middle of the aliphatic linker, four new pentamidines bearing S atoms were synthesized and also evaluated against MRSA strains. N,Nâ²-Dialkylated pentamidines with S atoms in the linker are the promising lead structures for antimicrobials development.
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Authors
Dorota Maciejewska, Jerzy Å»abiÅski, PaweÅ Kaźmierczak, Karolina Wójciuk, Marcin Kruszewski, Hanna Kruszewska,