| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10591901 | Bioorganic & Medicinal Chemistry Letters | 2013 | 7 Pages |
Abstract
A naphthalimide-Cu(II) ensemble was rationally designed and synthesized as a new turn-on fluorescent probe utilizing the 'chemosensing ensemble' method for detections of thiols (Cys, Hcy and GSH) with high selectivity over other α-amino acids. The recognition mechanism was attributed to the remove of Cu(II) from the naphthalimide-Cu(II) ensemble by thiols and the release of florescence of ligand 1. Remarkable fluorescence enhancements were therefore observed in the sensing process of thiols by the naphthalimide-Cu(II) ensemble in the vitro assays and in the fluorescence imaging in CHO cells with high sensitivity and selectivity.
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Authors
Yong Gang Shi, Jian Hua Yao, Yu Lian Duan, Qi Li Mi, Jian Hua Chen, Quan Qing Xu, Gao Zhang Gou, Ying Zhou, Jun Feng Zhang,