Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591926 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A group of cyclic imides (1-10) was designed for evaluation as a selective COX-2 inhibitors and investigated in vivo for their anti-inflammatory activity. Compounds 6a, 6b, 8a, 8b, 9a, 9b, 10a and 10b were proved to be potent COX-2 inhibitors with IC50 range of 0.1-4.0 μM. In vitro COX-1/COX-2 inhibition structure-activity studies identified compound 8a as a highly potent (IC50 = 0.1 μM), and an extremely selective [COX-2 (SI) > 1000] comparable to celecoxib [COX-2 (SI) > 384], COX-2 inhibitor that showed superior anti-inflammatory activity (ED50 = 72.4 mg/kg) relative to diclofenac (ED50 = 114 mg/kg). Molecular modeling was carried out through docking the designed compounds into the COX-2 binding site to predict if these compounds have analogous binding mode to the COX-2 inhibitors. The study showed that the homosulfonamide fragment of 8a inserted deep inside the 2°-pocket of the COX-2 active site, where the SO2NH2 group underwent H-bonding interaction with Gln192(2.95 Ã
), Phe518(2.82Â Ã
) and Arg513(2.63 and 2.73Â Ã
). Docking study of the synthesized compound 8a into the active site of COX-2 revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ibrahim A. Al-Suwaidan, Amer M. Alanazi, Adel S. El-Azab, Abdulrahman M. Al-Obaid, Kamal E.H. ElTahir, Azza R. Maarouf, Mohamed A. Abu El-Enin, Alaa A.-M. Abdel-Aziz,