Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592098 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
We describe the synthesis and biological evaluation of (+)-neopeltolide analogues with structural modifications in the oxazole-containing side chain. Evaluation of the antiproliferative activity of newly synthesized analogues against A549 human lung adenocarcinoma cells and PANC-1 human pancreatic carcinoma cells have shown that the C19-C20 and C26-C27 double bonds within the oxazole-containing side chain and the terminal methyl carbamate group are essential for potent activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haruhiko Fuwa, Takuma Noguchi, Masato Kawakami, Makoto Sasaki,