Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592099 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
In order to obtain self assembling, multivalent ligand for influenza virus hemagglutinin α-N-acetylneuraminyl-(2-6)-d-galactopyranose has been synthesized and bonded to a water soluble fullerene derivative using 1,3-dipolar cycloaddition click reaction. The aggregating amphiphilic compound did not inhibit the influenza virus hemagglutinin, but it proved to be an inhibitor of its neuraminidase with a 50% inhibitory concentration of 81 μM.
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Authors
Szilvia Tollas, Ilona Bereczki, Anikó Borbás, Gyula Batta, Evelien Vanderlinden, Lieve Naesens, Pál Herczegh,