| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592107 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jennifer R. Mazzone, Ryan C. Conyers, Abhai K. Tripathi, David J. Sullivan, Gary H. Posner,