| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592162 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Serotonin type 3 receptor partial agonists with nanomolar binding affinity and low to moderate intrinsic activity (IAÂ =Â 7-87% of 5-HT Emax) are described. Oral activity and favorable drug properties are provided for select compounds.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David D. Manning, Cheng Guo, Zhenjun Zhang, Kristen N. Ryan, Jennifer Naginskaya, Sok Hui Choo, Liaqat Masih, William G. Earley, Jonathan D. Wierschke, Amy S. Newman, Catherine A. Brady, Nicholas M. Barnes, Peter R. Guzzo,