| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592323 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A series of novel bivalent mimetics of annonaceous acetogenins have been designed, synthesized, and evaluated. Among these, compound 7 bearing a homopiperazine ring in the middle region exhibited more potent growth inhibitory activity and higher selectivity against cancer cells over normal cells by comparison with AA005. This work indicates that modification of the middle piperazine ring is a useful optimizing tool for the simplified acetogenin mimetics.
Related Topics
Physical Sciences and Engineering
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Authors
Yanghan Liu, Yongqiang Liu, Zhen Li, Guang-Biao Zhou, Zhu-Jun Yao, Sheng Jiang,