| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592334 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Novel potent and selective mineralocorticoid receptor antagonists were identified, utilizing heterocyclic amide replacements in the oxazolidinedione series. Structure-activity relationship (SAR) efforts focused on improving lipophilic ligand efficiency (LLE) while maintaining nuclear hormone receptor selectivity and reasonable pharmacokinetic profiles.
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Authors
Jason M. Cox, Hong D. Chu, Christine Yang, Hong C. Shen, Zhicai Wu, Jaume Balsells, Alejandro Crespo, Patricia Brown, Beata Zamlynny, Judyann Wiltsie, Joseph Clemas, Jack Gibson, Lisa Contino, JeanMarie Lisnock, Gaochao Zhou, Margarita Garcia-Calvo,