Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592357 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
Diverse functionalized representatives of various classes of sugars, such as thio-, anhydro-, and sulfamido-sugars and myo-inositol oxide, were synthesized and assessed for cytotoxicity against human cancer cell lines (A549, LoVo, MCF-7 and HeLa). The inositol oxide (4) was more active against MCF-7 cells (i.e., an estrogen-dependent breast cancer line), whereas all 3 sulfur-containing compounds showed strongest activity against A549 cells (i.e., a lung adenocarcinoma line). We propose to use a concept of functional 'CARB-pharmacophores' when evaluating a potential for the compounds' general antineoplastic activity. Future studies will determine the reasons for cell-type specificity of these compounds. The thio-sugar motif appears to be a promising lead for future developments.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zbigniew J. Witczak, Tomasz Poplawski, Anna Czubatka, Joanna Sarnik, Pawel Tokarz, Adam L. VanWert, Roman Bielski,