Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592358 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
We describe the synthesis of a series of new molecules containing phenol and triazoles moieties, compounds which have been evaluated for their ability to inhibit Bax/Bcl-xL interactions in cancer cells, by using BRET assays, and to induce cell death. Several derivatives exhibit a very promising activity, being more potent than the reference compounds acylpyrogallol A and ABT-737. These preliminary results demonstrate that derivatives of this family can be attractive to develop new molecules with potent anticancer activity.
Related Topics
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Authors
Duc Duy Vo, Fabien Gautier, Sophie Barillé-Nion, Philippe Juin, Nicolas Levoin, René Grée,