Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592359 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
By introducing various amino methyl groups into 12-position of berberrubine, a series of 12-(substituted aminomethyl) berberrubine derivatives were synthesized and evaluated for their anti-diabetic activity against type 2 diabetes mellitus. The results indicated that most of the prepared compounds exhibited moderate to good anti-diabetic activity, which were comparable to or even better than the berberine, the positive control rosiglitazone and insulin. Especially, compound 3b with an N-methyl piperazine-4-methyl group at C-12, exerted the most powerful anti-diabetic activity.
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Authors
Renjun Li, Jianbo Wu, Yun He, Li Hai, Yong Wu,