| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592365 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
Replacement of the ether linkage in the filorexant proved highly sensitive toward modification with an acetylene linkage providing compounds with the best in vitro and in vivo potency profiles.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott D. Kuduk, Jason W. Skudlarek, Christina N. Di Marco, Joseph G. Bruno, Mark A. Pausch, Julie A. O'Brien, Tamara D. Cabalu, Joanne Stevens, Joseph Brunner, Pamela L. Tannenbaum, Anthony L. Gotter, Christopher J. Winrow, John J. Renger,