Article ID Journal Published Year Pages File Type
10592367 Bioorganic & Medicinal Chemistry Letters 2014 5 Pages PDF
Abstract
Herein we report the design and synthesis of a series of novel bicyclic DGAT1 inhibitors with a carboxylic acid moiety. The optimization of the initial lead compound 7 based on in vitro and in vivo activity led to the discovery of potent indoline and quinoline classes of DGAT1 inhibitors. The structure-activity relationship studies of these novel series of bicyclic carboxylic acid derivatives as DGAT1 inhibitors are described.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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