Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592367 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Herein we report the design and synthesis of a series of novel bicyclic DGAT1 inhibitors with a carboxylic acid moiety. The optimization of the initial lead compound 7 based on in vitro and in vivo activity led to the discovery of potent indoline and quinoline classes of DGAT1 inhibitors. The structure-activity relationship studies of these novel series of bicyclic carboxylic acid derivatives as DGAT1 inhibitors are described.
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Physical Sciences and Engineering
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Authors
Gang Zhou, Pauline C. Ting, Grant Wishart, Nicolas Zorn, Robert G. Aslanian, Mingxiang Lin, Michelle Smith, Scott S. Walker, John Cook, Margaret Van Heek, Jean Lachowicz,