| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592386 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A novel series of water-soluble derivatives of limonin were synthesized by introducing various tertiary amines onto the C (7)-position of limonin. Ten target compounds were characterized and screened for their anti-inflammatory and analgesic activity in vivo. Compound 3c exhibited the strongest analgesic and anti-inflammatory activity among the limonin and its derivatives tested; its analgesic activity is more potent than that of aspirin and its anti-inflammatory activity is stronger than that of naproxen.
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Authors
Yun Yang, Xinhui Wang, Qihua Zhu, Guoqing Gong, Danmeng Luo, Aidou Jiang, Liyan Yang, Yungen Xu,