Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592388 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5α), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mohamed A. Ibrahim, Siva S. Panda, Antoinette S. Birs, Juan C. Serrano, Claudio F. Gonzalez, Khalid A. Alamry, Alan R. Katritzky,