| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592456 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A series of 1,3-thiazole derivatives were synthesized as potent, orally bioavailable S1P3-sparing S1P1 agonists. One of them, 24c, exhibited favorable efficacy in rat on host versus graft reaction (HvGR). The pharmacokinetic data for other compounds are shown as well.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masayoshi Asano, Tsuyoshi Nakamura, Yukiko Sekiguchi, Yumiko Mizuno, Takahiro Yamaguchi, Kazuhiko Tamaki, Takaichi Shimozato, Hiromi Doi-Komuro, Takashi Kagari, Wataru Tomisato, Ryotaku Inoue, Hiroshi Yuita, Keiko Oguchi-Oshima, Reina Kaneko,