| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592469 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A novel class of acetohydrazide derivatives containing 2-(phenylthiomethyl)-1H-benzo-[d]-imidazole moiety are described, their antitumor activitives against A549, HCT116, HepG2, PC-9, and A375 were determined by the MTT assay. Compounds 5a and 5d displayed excellent cancer inhibitory activity (IC50 4-17 μM).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents](/preview/png/10592469.png "First Page Preview: Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents")
Authors
Ting Liu, Changyan Sun, Xiumei Xing, Lingling Jing, Rui Tan, Youfu Luo, Wencai Huang, Hang Song, Zicheng Li, Yinglan Zhao,