Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592480 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Through synthesis and assays of peptidyl substrates, we could select substrates having peptidyl complementary against lipases. The best substrate showed 20-fold improved Km relative to non-peptidyl substrate. Using this information, we generated selective inhibitors. Lipase activities with peptidyl substrates were represented as fingerprints. Differences in fingerprints reflect different structures near active site of lipases, could be used for generating selective inhibitors.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sangeun Park, Jaehoon Yu,