| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592485 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The synthesis and design guided by SAR and SPR studies of novel quinazoline derivatives as MCHR1 antagonists are described. Compound 8 (DRL-21816) has emerged as a lead optimized candidate with a good cardiovascular safety window.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sanjita Sasmal, D. Balasubrahmanyam, Hariprasada R. Kanna Reddy, Gade Balaji, Gujjary Srinivas, Srisailam Cheera, Chandrasekhar Abbineni, Pradip K. Sasmal, Ish Khanna, V.J. Sebastian, Vikram P. Jadhav, Manvendra P. Singh, Rashmi Talwar, J. Suresh,