| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592509 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
The synthesis and structure-activity relationship studies of isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors are discussed. The pharmacokinetic profile of 10 and 21 with adequate CNS penetration, required for in vivo Parkinson's disease models, are disclosed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Abhisek Banerjee, Pravin S. Yadav, Malini Bajpai, Ramachandra Rao Sangana, Srinivas Gullapalli, Girish S. Gudi, Laxmikant A. Gharat,