Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592552 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Three new mycophenolic acid derivatives, penicacids A-C (1-3), together with two known analogues, mycophenolic acid (MPA, 4) and 4â²-hydroxy-MPA (5), were isolated from a fungus Penicillium sp. SOF07 derived from a South China Sea marine sediment. The structures of compounds 1-3 were elucidated on the basis of MS and NMR (1H, 13C, HSQC and HMBC) data analyses and comparisons with the known compounds. Structure-activity relationship studies of compounds 1-5 focused on inosine-monophosphate dehydrogenase inhibition revealed that hydroxylation at C-4â², methylation at C-7-OH, dual hydroxylation at C-2â²/C-3â² double bond of MPA diminished bioactivity whereas glucosyl hydroxylation at C-4â² correlated to bioactivity comparable to that observed for MPA.
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Authors
Ziming Chen, Zhihui Zheng, Hongbo Huang, Yongxiang Song, Xuelian Zhang, Junying Ma, Bo Wang, Changsheng Zhang, Jianhua Ju,