| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592564 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.
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Authors
Willmen Youngsaye, Chris Dockendorff, Benjamin Vincent, Cathy L. Hartland, Joshua A. Bittker, Sivaraman Dandapani, Michelle Palmer, Luke Whitesell, Susan Lindquist, Stuart L. Schreiber, Benito Munoz,