| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592584 | Bioorganic & Medicinal Chemistry Letters | 2014 | 7 Pages |
Abstract
Expansion of the acetonitrile-assisted, diphosgene-mediated synthesis of bicyclic pyrimidines (compound B) expeditiously afforded dual orexin receptor antagonists (DORAs) with excellent potency and rat sleep efficacy. In vitro bioactivation studies on key compounds are also described.
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Authors
Anthony J. Roecker, Swati P. Mercer, C. Meacham Harrell, Susan L. Garson, Steven V. Fox, Anthony L. Gotter, Thomayant Prueksaritanont, Tamara D. Cabalu, Donghui Cui, Wei Lemaire, Christopher J. Winrow, John J. Renger, Paul J. Coleman,