| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592629 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
Screening a nuclear receptor compound subset in a RORc biochemical binding assay revealed a benzylic tertiary sulfonamide hit. Herein, we describe the identification of compounds with improved RORc biochemical inverse agonist activity and cellular potencies. These improved compounds also possessed appreciable selectivity for RORc over other nuclear receptors.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Benjamin P. Fauber, Olivier René, Brenda Burton, Christine Everett, Alberto Gobbi, Julie Hawkins, Adam R. Johnson, Marya Liimatta, Peter Lockey, Maxine Norman, Harvey Wong,