Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592642 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Novel triazolopyrimidine acylsulfonamides class of antimycobacterial agents, which are mycobacterial acetohydroxyacid synthase (AHAS) inhibitors were designed by hybridization of known AHAS inhibitors such as sulfonyl urea and triazolopyrimidine sulfonamides. This Letter describes the synthesis and SAR studies of this class of molecules by variation of two parts of the molecule, the phenyl and triazolopyrimidine rings. SAR study describes optimisation of enzyme potency, whole cell potency and evidence of mechanism of action.
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Authors
Vikas Patil, Manoj Kale, Anandkumar Raichurkar, Brahatheeswaran Bhaskar, Dwarakanath Prahlad, Meenakshi Balganesh, Santosh Nandan, P. Shahul Hameed,