Article ID Journal Published Year Pages File Type
10592696 Bioorganic & Medicinal Chemistry Letters 2016 7 Pages PDF
Abstract
Based on the binding mode of quinolones with HCV NS5B, 2-alkyl-N-arylquinolones and 1,6-naphthyridine-4,5-diones were designed and discovered as novel HCV inhibitors with submicromolar cellular replican potency.105
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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency
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