Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido[2,3-d]pyrimidine derivatives as promising anticancer and antibacterial agents

Novel 1,2,3-triazole/isoxazole functionalized pyrido[2,3-d]pyrimidine derivatives 6a-c, 7a-h and 8a-e were prepared and screened for anticancer activity. Compounds 7d and 7h showed highest activity. All the compounds also screened for antibacterial activity and identified promising compounds. Further evaluated for minimum inhibitory concentration to validate the data.156