| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592735 | Bioorganic & Medicinal Chemistry Letters | 2014 | 7 Pages |
Abstract
Ingenol 3-benzoates were investigated with respect to chemical stability, pro-inflammatory effects, cell death induction and PKCδ activation. A correlation between structure, chemical stability and biological activity was found and compared to ingenol mebutate (ingenol 3-angelate) used for field treatment of actinic keratosis. We also provided further support for involvement of PKCδ for induction of oxidative burst and cytokine release. Molecular modeling and dynamics calculations corroborated the essential interactions between key compounds and C1 domain of PKCδ.
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Authors
Gunnar Grue-Sørensen, Xifu Liang, Kristoffer MÃ¥nsson, Per Vedsø, Morten Dahl Sørensen, Anke Soor, Martin Stahlhut, Malene Bertelsen, Karen Margrethe Engell, Thomas Högberg,